Ranitidine inhibits gastric acid production and is used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux (GERD). Ranitidine can be used along side other antihistamines to treat skin conditions. Common brand names are Aceptin, Aciloc, Aciran, Ameket, Contracid, Danitin, Entac, Loracid, Ranitab, Raxide, Zantac, and Zidaxim. Ranitidine is classified as a Histamine H2 receptor antagonist and an Antiulcer.
Ranitidine is used for short-term treatment of active duodenal ulcer. It is also used in the prevention of duodenal ulcer recurrence. Ranitidine can be used for the treatment of active benign gastric ulcer, pathologic GI hypersecretory conditions, acute gastroesophageal reflux disease (GERD), and erosive esophagitis.
PO: ADULTS, ELDERLY: 150 mg 2 times per day or 300 mg at bedtime. MAINTENANCE: 150 mg at bedtime. CHILDREN: 2-4 mg/kg/day in divided doses 2 times per day. Maximum: 300 mg per day.
PO: ADULTS, ELDERLY: 150 mg 4 times a day. MAINTENANCE: 150mg 2 times a day or 300 mg at bedtime. CHILDREN: 4-10 mg/kg/day in 2 divided doses. Maximum: 600 mg per day.
PO: ADULTS, ELDERLY: 150 mg 2 times a day. May increase up to 6g per day.
IV/IM: ADULTS, ELDERLY: 50mg per dose every 6-8 hours. Maximum: 400mg per day. CHILDREN: 2-4 mg/kg/day in divided doses every 6-8 hours. Maximum: 200mg per day.
IV: Initially, 1.5 mg/kg/dose, then 1.5-2 mg/kg/day in divided doses every 12 hours.
PO: 2 mg/kg/day in divided doses every 12 hours.
PO: 150 mg every 24 hours.
IM/IV: 50mg every 18-24 hours.
Ranitidine inhibits histamine action at the H2 receptors of gastric parietal cells. It inhibits gastric acid secretion and reduces volume and hydrogen ion concentration of gastric juice.
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